Basic Information

Symbol
hsa-mir-19b-2
RNA class
miRNA miRNA hairpin
Alias
MIR19B2 MicroRNA 19b-2 Hsa-MiR-19b-2-5p Hsa-MiR-19b-3p Hsa-Mir-19b-2 MIRN19B2 Hsa-Mir-19-P2c_pre MIMAT0004492 MIMAT0000074 MiR-19b-2 MI0000075
Location (GRCh38)
X:134169671-134169766
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-19b-2
Sequence length
96 nt
GC content
0.3438

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-39.90 kcal/mol
Thermodynamic ensemble
Free energy: -41.23 kcal/mol
Frequency: 0.1150
Diversity: 12.74
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((((....((((((((((((((((((((((((((....(((((((....)))))))....))))))).)).)))))))))))))))))))))))
Thermodynamic Ensemble Prediction
((((((....((((((((((((((((((((((((({..{,(({((((,...,}))))),},,))))))),)}.)))))))))))))))))))))))
Forensic Context

A review of the literature indicates that the mir-19b-2 is dysregulated in the fetal hippocampus following prenatal alcohol exposure, as identified in studies using human, mouse, rat, zebrafish, and sheep models [Mandal et al. DOI:10.1002/JAT.3504]. A review of literature indicates that in rhesus macaques (Macaca mulatta) subjected to whole thorax irradiation, mir-19b-2 was identified as a feature in a Day 3 three-group survival prediction model, which achieved 71% accuracy in forecasting whether an animal would die in less than 90 days, between 90 and 269 days, or survive the 270-day study [May et al. DOI:10.1038/s41598-022-16316-x]. In studies on prenatal alcohol toxicity, mir-19b-2 was reported as down-regulated after 7 days of ethanol exposure in suspension culture in embryonal cell differentiation models [Mandal et al. DOI:10.1002/Jat.3504].