Basic Information

Symbol
hsa-mir-103a-2
RNA class
miRNA miRNA hairpin
Alias
MIR103A2 MicroRNA 103a-2 Hsa-MiR-103a-2-5p Hsa-MiR-103a-3p Hsa-Mir-103a-2 Hsa-Mir-103-2 MicroRNA 103-2 MIRN103-2 MIR103-2 Hsa-Mir-103-P2_pre MIMAT0000101 MIMAT0009196 Mir-103a-2 MI0000108
Location (GRCh38)
20:3917494-3917571
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Sudden cardiac death diagnosis Other applications
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-103a-2
Sequence length
78 nt
GC content
0.4487

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-28.10 kcal/mol
Thermodynamic ensemble
Free energy: -30.46 kcal/mol
Frequency: 0.0216
Diversity: 8.99
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..((.(((((((((.((.(((((((((((.(((.(.(.....).))))))))))))))).)))))..)))))).))..
Thermodynamic Ensemble Prediction
..({.(((((((({{((.(((((((((({{(((.,.(.....},))))))))))))))).))))),.}))))).})..
Forensic Context

A study in humans identified the mir-103a as upregulated in serum from patients with mild traumatic brain injury (mTBI) and found it targets 2087 genes, with its signaling associated with specific pathways including MAPK, TGF-β, and insulin signaling [Matyasova et al. DOI:10.4149/gpb_2021038]. Another study in humans found the mir-103a was upregulated in the plasma of young patients with ST-segment elevation myocardial infarction (STEMI) as identified by small RNA sequencing [Tong et al. DOI:10.3390/ijms19051467]. A study in human autopsy-derived brain tissues demonstrated that the mir-103a was selected as a highly stable reference gene for quantitative RT-qPCR analysis in both fresh and formalin-fixed paraffin-embedded (FFPE) specimens, as well as in archived FFPE blocks stored for up to nine years [Lv et al. DOI:10.1007/s00414-019-02210-1]. This stability, validated using the RefFinder tool, enables accurate normalization for molecular analyses in forensic pathology, where short amplicon markers showed high quantification consistency between paired sample types.