Basic Information

Symbol
hsa-mir-190a
RNA class
miRNA miRNA hairpin
Alias
MIR190A MicroRNA 190a Hsa-MiR-190a-5p Hsa-Mir-190 MicroRNA 190 MIRN190 MIR190 Hsa-Mir-190-P1_pre Hsa-MiR-190a-3p Hsa-Mir-190a MIMAT0000458 MIMAT0026482 MI0000486 Mir-190a MiR-190
Location (GRCh38)
13:40727828-40727875
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Sudden death from CNS diseases Other applications
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-190a
Sequence length
85 nt
GC content
0.3412

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-31.60 kcal/mol
Thermodynamic ensemble
Free energy: -33.03 kcal/mol
Frequency: 0.0979
Diversity: 7.10
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((((.(.(((((.((((((((((((((((..(((((..........)))))))))))))))))))))..))))).).))))).
Thermodynamic Ensemble Prediction
.(((((.(.(((((.((((((((((((((((..(((((..........))))))))))))))))))))),.))))).).))))).
Forensic Context

A study in humans demonstrated that the mir-190a was significantly downregulated in plasma from patients with isolated spinal cord injury (SCI) at emergency room admission compared to healthy controls, and this suppression was markedly stronger in SCI patients than in polytrauma patients without neurotrauma [Hörauf et al. DOI:10.3390/ijms262210954]. A study in mice demonstrated that the mir-190a was identified as dysregulated by RNA-seq in ischemic heart tissue following myocardial infarction, though it was not previously linked to MI [Williams et al. DOI:10.1152/physiolgenomics.00041.2020]. In a separate review, the mir-190a was also reported as upregulated in the penis of diabetic erectile dysfunction mouse models based on microarray screening [Song et al. DOI:10.3389/fendo.2022.1034043].