Forensic Context

A study in humans identified the miR-103a-3p as upregulated in serum from patients with mild traumatic brain injury (mTBI) and as a potential biomarker upregulated in the plasma of young patients with acute coronary syndrome (ACS) via small RNA sequencing [Matyasova et al. DOI:10.4149/gpb_2021038][Tong et al. DOI:10.3390/ijms19051467]. A study in mice demonstrated that the miR-103a-3p exhibited significant upregulation in antemortem skin lesions within 0-24 hours in hanging cases, where it was associated with the suppression of NF-κB-mediated inflammatory pathways [Fanzhang Lei et al. DOI:10.1093/gpbjnl/qzag007].