Basic Information

Symbol
hsa-mir-194-1
RNA class
miRNA miRNA hairpin
Alias
MIR194-1 MicroRNA 194-1 Hsa-MiR-194-5p Hsa-Mir-194-1 MIRN194-1 Hsa-Mir-194-P1_pre MIMAT0000460 Mir-194-1 MI0000488 hsa-mir-194
Location (GRCh38)
1:220118157-220118241
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Cause of death analysis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-194-1
Sequence length
85 nt
GC content
0.4118

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-38.40 kcal/mol
Thermodynamic ensemble
Free energy: -39.79 kcal/mol
Frequency: 0.1055
Diversity: 4.93
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((((.(((((((.(((((((((.((((((.((((..((......)).)))))))))).))))))))).)))))))..))))).
Thermodynamic Ensemble Prediction
.(((((.(((((((.(((((((((.((((((.((((..{(....,,},.)))))))))).))))))))).)))))))..))))).
Forensic Context

A study in humans demonstrated that circulating hsa-miR-194 was identified as a potential biomarker for myocardial infarction, showing a significant increase in the plasma of male patients compared to healthy controls using next-generation sequencing [Baulina et al. DOI:10.1016/j.yjmcc.2018.07.129]. In mice, mmu-miR-194-5p was identified as a candidate biomarker for lethal radiation injury, with its expression significantly decreased in serum on day one specifically after lethal irradiation and showing a positive correlation with lymphocyte counts [Jia et al. DOI:10.1016/j.toxlet.2024.07.911]. In mice, research on radiation biodosimetry showed that the mir-194 exhibited differential expression after radiation injury in C3H/HeJ mice [Martello et al. DOI:10.1667/RADE-23-00007.1].