Forensic Context

A study in mice demonstrated that the miR-194-5p (mmu-miR-194-5p) was a candidate biomarker for lethal radiation injury, with its expression in serum significantly decreased to 61% on day 1 specifically after a lethal 10 Gy total body irradiation and showing a positive correlation with lymphocyte counts (r=0.5329) [Jia et al. DOI:10.1016/j.toxlet.2024.07.911]. In human forensic science, a multi-class support vector machine model for body fluid identification was constructed and validated, though the specific forensic application of hsa-miR-194-5p was not among the 28 evaluated markers in this particular experimental workflow [Li et al. DOI:10.1016/j.fsigen.2024.103180]. A study in humans demonstrated that the miR-194-5p showed no significant expression differences in plasma or hippocampal tissue between a single case of sudden unexpected death in epilepsy and ten control forensic autopsy cases [De Matteis et al. DOI:10.1016/J.Legalmed.2017.12.003].