Forensic Context

A study in human heart tissue from road traffic accident victims demonstrated that the miR-195-5p showed a significant, time-dependent reduction in expression over a 196-hour post-mortem interval, with a 41-fold lower mean expression at 196 hours compared to 12 hours, indicating its potential for estimating the post-mortem interval during advanced decomposition stages [Singh et al. DOI:10.1016/j.scijus.2023.04.011]. A study in rats demonstrated that the miR-195-5p was up-regulated (2.25 fold) in the nucleus accumbens of animals with chronic methamphetamine-induced addiction compared to those receiving acute treatment [Sim et al. DOI:10.1007/S11011-017-0061-X]. In forensic contexts, the miR-195-5p has been examined as a reference marker for lung tissue in postmortem interval estimation and was significantly upregulated in the brain tissue of suicide victims, indicating its utility in cause-of-death analysis [Song et al. DOI:10.1007/s00414-023-03091-1].