Basic Information

Symbol
hsa-mir-196a-2
RNA class
miRNA miRNA hairpin
Alias
MIR196A2 MicroRNA 196a-2 Hsa-MiR-196a-3p Hsa-MiR-196a-5p Hsa-Mir-196a-2 Hsa-Mir-196-2 MicroRNA 196-2 MIRN196-2 MIRN196A2 Hsa-Mir-196-P4_pre MIMAT0000226 MIMAT0004562 Mir-196a-2 MI0000279 hsa-mir-196a
Location (GRCh38)
3:52294219-52294308
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Other applications
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-196a-2
Sequence length
110 nt
GC content
0.4818

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-50.80 kcal/mol
Thermodynamic ensemble
Free energy: -52.62 kcal/mol
Frequency: 0.0523
Diversity: 7.42
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..(((((..(((((((.((((((((((((((((((.((((((((((.((........)))))))))))).))))))))))))))))))...)))))))...).))))...
Thermodynamic Ensemble Prediction
,.(((({..(((((((.((((((((((((((((((.((((((((((.((,,....},),)))))))))).))))))))))))))))))...)))))))...).)))).}.
Forensic Context

A study in humans demonstrated that the mir-196a was not significantly regulated with age in peripheral blood from physiologically unaffected individuals, serving as a negative control [Meder et al. DOI:10.1373/clinchem.2014.224238]. In human skin burn pathology, the mir-196a was downregulated in burn hypertrophic scar and its derived fibroblasts compared to normal fibroblasts and was also downregulated in heat-shocked fibroblasts four hours post-burn [Siu et al. DOI:10.1111/wrr.13100]. In doping control research, the mir-196a was identified as a potential microRNA marker for stored red blood cells in the context of autologous blood transfusion, as its expression changed upon storage of red blood cells at 4°C [Reichel DOI:10.1016/J.Forsciint.2011.07.031].