Basic Information

Symbol
hsa-mir-197
RNA class
miRNA miRNA hairpin
Alias
MIR197 MicroRNA 197 Hsa-MiR-197-3p Hsa-MiR-197-5p Hsa-Mir-197 MIRN197 Hsa-Mir-197_pre MIMAT0000227 MIMAT0022691 MI0000239 MiRNA197 MiR-197
Location (GRCh38)
1:109598893-109598967
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Chronological age estimation Sudden cardiac death diagnosis Tissue/body fluid identification
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-197
Sequence length
75 nt
GC content
0.6267

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-41.40 kcal/mol
Thermodynamic ensemble
Free energy: -41.75 kcal/mol
Frequency: 0.5643
Diversity: 3.21
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((((((.((((.(((((((..(((((.((((((....))).))).)))))..))))))).)))).))))))))
Thermodynamic Ensemble Prediction
((((((((.((((.(((((((..(((((.((((((....))).))).)))))..))))))).)))).))))))))
Forensic Context

A study in humans demonstrated that the mir-197 was significantly positively correlated with age in peripheral blood, with a correlation coefficient of 0.433 and a raw P value of 1.28E-05 in a microarray cohort [Meder et al. DOI:10.1373/clinchem.2014.224238]. In a separate human study on myocardial fibrosis after acute myocardial infarction, the mir-197 was identified as the most down-regulated DEmiRNA and was part of a potential ceRNA network involving LINC00664 and JAK2, with its expression validated by qRT-PCR [Wang et al. DOI:10.2147/IJGM.S329391]. A study in human clinical samples demonstrated that the mir-197 showed significant differential expression, with the highest mean expression in fertile semen, followed by oligospermic semen, azoospermic semen, and vaginal fluid [Alsaeed et al. DOI:10.1007/s12024-024-00831-6].