Basic Information

Symbol
hsa-mir-1976
RNA class
miRNA miRNA hairpin
Alias
MIR1976 MicroRNA 1976 Hsa-Mir-1976 Hsa-MiR-1976 MIMAT0009451 MI0009986
Location (GRCh38)
16:15010321-15010397
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-1976
Sequence length
52 nt
GC content
0.6154

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-33.00 kcal/mol
Thermodynamic ensemble
Free energy: -33.60 kcal/mol
Frequency: 0.3796
Diversity: 3.90
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
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Forensic Context

A study in humans demonstrated that the mir-1976 is upregulated in burn hypertrophic scar and its derived fibroblasts compared to normal fibroblasts [Siu et al. DOI:10.1111/wrr.13100], and another human study identified the mir-1976 as an intermediate-abundance plasma exosomal miRNA upregulated in coronary artery disease patients compared to acute myocardial infarction patients, where it was part of an 18-miRNA panel with diagnostic potential [Guo et al. DOI:10.21037/atm-20-2337]. A study in humans demonstrated that plasma exosomal hsa-miR-1976 was identified as a diagnostic biomarker for acute myocardial infarction (AMI), where it was upregulated in the coronary artery disease (CAD) group compared to the AMI group [Guo et al. DOI: 10.21037/atm-20-2337].