Basic Information
Symbol
hsa-miR-198
RNA class
miRNA
mature miRNA
Alias
hsa-miR-198
MIR198
MicroRNA 198
Sequence & Structure
Secondary Structure
Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-13.80 kcal/mol
Thermodynamic ensemble
Free energy:
-14.90 kcal/mol
Frequency:
0.5119
Diversity:
3.20
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
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Forensic Context
A study in humans demonstrated that the miR-198 is upregulated four days post-burn in deep partial thickness burn skin compared to normal skin [Siu et al. DOI:10.1111/wrr.13100]. A study in mice demonstrated that elevated expression of the miR-198 in chronic wounds impairs keratinocyte migration and re-epithelialization [Badanina et al. DOI:10.3390/ijms262010060]. Research in human denatured dermis and heat-damaged fibroblasts further confirmed its dysregulation in thermal-induced skin injury, associating it with impaired wound healing processes [Wang & Zhou DOI:10.1007/s00438-024-02183-w].