Basic Information

Symbol
hsa-mir-199a-1
RNA class
miRNA miRNA hairpin
Alias
MIR199A1 MicroRNA 199a-1 Hsa-MiR-199a-5p Hsa-MiR-199a-3p Hsa-Mir-199a-1 Hsa-MiR-199b-3p MIRN199A1 Hsa-Mir-199-P3-V1_pre Hsa-Mir-199-P3-V2_pre Hsa-Mir-199-P3-V3_pre MIMAT0000231 MIMAT0000232 MiR-199a-3p Mir-199a-1 MIR-199-S MI0000242 hsa-mir-199a
Location (GRCh38)
14:101046455-101046538
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-199a-1
Sequence length
71 nt
GC content
0.5070

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-28.50 kcal/mol
Thermodynamic ensemble
Free energy: -30.39 kcal/mol
Frequency: 0.0468
Diversity: 8.61
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
((({(,(((((((.((((((({,(((.((.(((...}))..},,,.))))))))))).)))))))}).)))
Forensic Context

A study in humans demonstrated that the mir-199a is markedly upregulated in trauma plasma and contains pro-inflammatory nucleotide motifs, with a panel including this biomarker distinguishing trauma from healthy controls with a cross-validated AUROC of 0.98 [Ren et al. DOI:10.1016/j.isci.2025.113569]. In a separate human study on deep burn wounds, the mir-199a was found to be down-regulated in denatured dermis compared to normal skin, with a measured fold change of 0.4363 [Liang et al. DOI:10.1016/j.burns.2011.10.014]. A study in rats demonstrated that miR-199a-3p was significantly down-regulated in the cortex and midbrain following fatal ligature strangulation, while miR-199a-5p showed no significant change in any brain region [Feng et al. DOI:10.1097/PAF.0000000000000298].