Basic Information

Symbol
hsa-mir-199b
RNA class
miRNA miRNA hairpin
Alias
MIR199B MicroRNA 199b Hsa-MiR-199b-3p Hsa-MiR-199b-5p Hsa-Mir-199b Hsa-MiR-199a-3p MIRN199B Hsa-Mir-199-P2-V3_pre Hsa-Mir-199-P2-V2_pre Hsa-Mir-199-P2-V1_pre MIMAT0004563 MIMAT0000263 MI0000282 Mir-199b
Location (GRCh38)
9:128244721-128244830
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Sudden unexpected death diagnosis Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-199b
Sequence length
110 nt
GC content
0.5273

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-42.10 kcal/mol
Thermodynamic ensemble
Free energy: -43.98 kcal/mol
Frequency: 0.0470
Diversity: 9.11
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((.((((.....(((((((.(((((.(((((((.(((((((.((((.(((..........))).))))))))))).))))))).))))).))).))))......))))))
Thermodynamic Ensemble Prediction
{(.((((.....(((({(({(((((.(((((((.(((((((.((((.((({....,,...,)).))))))))))).))))))).))))).))).))))......))))))
Forensic Context

A study in severely injured human patients identified 69 differentially expressed microRNAs, with the mir-199b showing an indirect correlation with arterial blood gas PaCO2 levels [Uhlich et al. DOI:10.1016/j.surg.2014.06.017]. In a separate study on human sepsis, RNA-seq analysis identified the mir-199b as part of a constructed competing endogenous RNA network, where it was predicted to interact with TGFBR3 [Zhang et al. DOI:10.1186/s12920-023-01460-8]. A study in mice demonstrated that the mir-199b was a predictive biomarker for survival, with lower circulating abundance associated with reduced survival in C3H mice at day 2 post whole thorax irradiation, and it was also differentially expressed in C3H heart tissue [Rogers et al. DOI:10.1371/journal.pone.0232411]. In human sepsis research, hsa-miR-199b-5p was identified as a differentially expressed microRNA upregulated in sepsis patients compared to healthy controls [Li et al. DOI:10.1038/s41598-025-89946-6].