Basic Information

Symbol
hsa-mir-20b
RNA class
miRNA miRNA hairpin
Alias
MIR20B MicroRNA 20b Hsa-MiR-20b-5p Hsa-MiR-20b-3p Hsa-Mir-20b MIRN20B Hsa-Mir-17-P4c_pre MIMAT0001413 MIMAT0004752 MI0001519 Mir-20b
Location (GRCh38)
X:134169809-134169877
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification Chronological age estimation
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-20b
Sequence length
69 nt
GC content
0.4493

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-29.60 kcal/mol
Thermodynamic ensemble
Free energy: -30.30 kcal/mol
Frequency: 0.3226
Diversity: 5.52
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
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Forensic Context

A study in human peripheral blood mononuclear cells demonstrated that the mir-20b was upregulated at a 1 Gy radiation dose, cooperating with miR-17-5p and predicted to interact with and downregulate many target genes, with enrichment in the thyroid cancer pathway via TCF7 [Lee et al. DOI:10.1155/2014/456323]. In a separate human study using peripheral whole blood, the mir-20b was significantly negatively correlated with age in a microarray cohort [Meder et al. DOI:10.1373/clinchem.2014.224238]. A study in human clinical samples demonstrated that the mir-20b showed statistically significant expression differences (P<0.001) between vaginal fluid, fertile semen, and infertile semen (oligospermia and azoospermia), with the highest mean expression in fertile semen [Shimaa Ahmed Alsaeed et al. DOI:10.1007/s12024-024-00831-6].