Forensic Context

A study in human peripheral blood mononuclear cells demonstrated that the miR-20b-3p is upregulated at 1 Gy of fractionated radiation exposure and cooperates with miR-17-5p to downregulate target genes, with enrichment in pathways such as thyroid cancer [Lee et al. DOI:10.1155/2014/456323]. In human skin, the miR-20b-3p is downregulated in burn hypertrophic scar and its derived fibroblasts compared to normal fibroblasts, but is upregulated 24 hours post-injury in skin wounds [Siu et al. DOI:10.1111/wrr.13100]. A study in humans with atrial fibrillation identified the miR-20b-3p as a common differentially expressed microRNA across baseline, 12-month, and 24-month disease stages via sequencing [Wang et al. DOI:10.1016/j.hrtlng.2020.03.021]. In mice, ionizing radiation-induced liver injury caused a significant upregulation of the miR-20b-3p (Log2 FC: 1.13), as confirmed by deep sequencing analysis [Lu et al. DOI:10.1002/cbin.10627].