Basic Information

Symbol
hsa-mir-200a
RNA class
miRNA miRNA hairpin
Alias
MIR200A MicroRNA 200a Hsa-MiR-200a-3p Hsa-MiR-200a-5p Hsa-Mir-200a MIRN200A Hsa-Mir-8-P2a_pre MIMAT0001620 MIMAT0000682 MI0000737 Mir-200a
Location (GRCh38)
1:1167863-1167952
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Individual identification Drug abuse diagnoses Other applications
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-200a
Sequence length
90 nt
GC content
0.5556

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-47.10 kcal/mol
Thermodynamic ensemble
Free energy: -48.15 kcal/mol
Frequency: 0.1828
Diversity: 7.05
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((((.(((.(((((((((((((((((((((((((.....)))))...........)))))))))))).)))))))).))).).)))).
Thermodynamic Ensemble Prediction
.((((,,(((.(((((((((((((((((((((((((.....))))}.......,..,)))))))))))).)))))))).))).).)))).
Forensic Context

A study in humans identified hsa-miR-200a as one of 66 differentially expressed miRNAs in denatured dermis from deep burn patients, where it was down-regulated 0.0371-fold compared to paired normal skin [Liang et al. DOI:10.1016/j.burns.2011.10.014]. A separate study in humans using miRNA sequencing identified mir-200a as one of nine miRNAs differentially expressed across five pairs of monozygotic twins, though subsequent qPCR validation showed its differential expression was reproduced in only one or two pairs and it was not selected for further forensic validation [Wang et al. DOI:10.1016/j.fsigen.2025.103230]. A study in rats demonstrated that the mir-200a was upregulated 24.03-fold in the corpus cavernosum of obese animals with erectile dysfunction [Bai et al. DOI:10.1016/j.esxm.2017.06.006], while research in mice identified the miR-8 family, which includes the mir-200a, as highly enriched and cocaine-regulated at striatal synapses [Eipper-Mains et al. DOI:10.1261/Rna.2775511].