Basic Information

Symbol
hsa-mir-200b
RNA class
miRNA miRNA hairpin
Alias
MIR200B MicroRNA 200b Hsa-MiR-200b-3p Hsa-MiR-200b-5p Hsa-Mir-200b MIRN200B Hsa-Mir-8-P1a_pre MIMAT0000318 MIMAT0004571 MI0000342 Mir-200b
Location (GRCh38)
X:147230720-147230843
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-200b
Sequence length
95 nt
GC content
0.6000

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-44.60 kcal/mol
Thermodynamic ensemble
Free energy: -45.49 kcal/mol
Frequency: 0.2370
Diversity: 5.22
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...((..((((..((((.(.(((((((((((((((.((((((..((......)))))))).))))))))))).)))).).)))).)))).))...
Thermodynamic Ensemble Prediction
...((..((((..((((.(.(((((((((((((((.((((((.{({......)))))))).))))))))))).)))).).)))).)))).))...
Forensic Context

A study in human deep burn patients identified hsa-miR-200b as significantly down-regulated in denatured dermis compared to paired normal skin, with a 0.0253-fold change [Liang et al. DOI:10.1016/j.burns.2011.10.014]. A subsequent review confirmed its downregulation in human skin four days post-burn and further associated its decreased expression with burn-induced hypertrophic scar tissue and derived fibroblasts [Siu et al. DOI:10.1111/wrr.13100]. A study in a porcine model of cardiogenic shock demonstrated that the mir-200b is a hypoxia-sensitive circulating marker whose serum abundance is decreased following the induction of cardiogenic shock and is subsequently restored following mechanical ventricular unloading with pVAD support [Riehle et al. DOI:10.3389/fcvm.2022.881067]. Its expression levels were positively correlated with cardiac output, identifying it as a potential prognostic biomarker for organ hypoperfusion and ischemia in this acute condition.