Basic Information

Symbol
hsa-mir-200c
RNA class
miRNA miRNA hairpin
Alias
MIR200C MicroRNA 200c Hsa-MiR-200c-5p Hsa-MiR-200c-3p Hsa-Mir-200c MIRN200C Hsa-Mir-8-P1b_pre MIMAT0004657 MIMAT0000617 MI0000650 Mir-200c
Location (GRCh38)
5:149062313-149062409
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification Mechanical injury analysis Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-200c
Sequence length
68 nt
GC content
0.5588

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-30.80 kcal/mol
Thermodynamic ensemble
Free energy: -32.14 kcal/mol
Frequency: 0.1143
Diversity: 7.25
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
.(((((((((((((.((((((((.(((.((........))))).)))))))).)))))).)))}})))
Forensic Context

A study in humans identified hsa-miR-200c as a previously reported marker for saliva identification, but subsequent genome-wide screening and validation found it showed poor body fluid-specific expression, as it was also highly expressed in vaginal secretions, limiting its forensic utility for distinguishing saliva [Park et al. DOI:10.1002/elps.201400075]. In a separate human study on burn wounds, the mir-200c was found to be down-regulated in denatured dermis compared to normal skin, with a 0.0224-fold change, though its specific role in wound healing pathways was not experimentally investigated in that context [Liang et al. DOI:10.1016/j.burns.2011.10.014]. A systematic review of human, mouse, rat, and pig studies found that the mir-200c was investigated for postmortem interval (PMI) estimation in lung tissue [Cianci et al. DOI:10.3390/ijms25158185].