Forensic Context

A study in humans demonstrated that the mir-202 was significantly downregulated in plasma-derived exosomes from trauma patients with severe injury compared to operative controls, and it is expressed in bone marrow mesenchymal stem cells where it reduces expression of inflammatory cytokines [Munley et al. DOI:10.1097/TA.0000000000004225]. A study in rats demonstrated that rno-miR-202-5p was significantly upregulated in left ventricular tissue from a post-infarction heart failure model, as identified by high-throughput sequencing and validated by qRT-PCR [Liu et al. DOI:10.1371/journal.pone.0160920]. In the context of male infertility, the mir-202 was identified as a biological regulator that blocks differentiation and sustains stem cell identity in spermatogonial stem cells by targeting Rbfox2, and prevents precocious differentiation and meiotic initiation by targeting STRA8 and DMRT6 in various species, as mentioned in a review [Doghish et al. DOI:10.1007/s00210-024-03594-7].