Basic Information

Symbol
hsa-mir-203a
RNA class
miRNA miRNA hairpin
Alias
MIR203A MicroRNA 203a Hsa-MiR-203a-3p Hsa-Mir-203 MicroRNA 203 MIRN203 MIR203 Hsa-Mir-203-V2_pre Hsa-Mir-203-V1_pre Hsa-MiR-203a-5p Hsa-Mir-203a MIMAT0000264 MIMAT0031890 MI0000283 MiRNA203 Mir-203a MiR-203
Location (GRCh38)
14:104117405-104117514
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification Other applications
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-203a
Sequence length
110 nt
GC content
0.5727

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-56.40 kcal/mol
Thermodynamic ensemble
Free energy: -58.91 kcal/mol
Frequency: 0.0170
Diversity: 7.78
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((((..(.(.(((.(((((((((.(((((((((.((((.((((.((((((......).))))))))).)))).))))))))).))))))))).))).).)..))))).
Thermodynamic Ensemble Prediction
.{((((..(.(,(((.(((((((((.(((((((((.((((.{((,{(((((,,,....).))))))))}.)))).))))))))).))))))))).))).),)..))))}.
Forensic Context

A study in humans demonstrated that hsa-miR-203a-3p is a microRNA marker used for differentiating venous blood and menstrual blood from saliva and vaginal secretion in forensic body fluid identification [Sauer et al. DOI:10.1016/j.fsigen.2016.01.018]. In a separate investigation on human organ tissues, hsa-miR-203a-3p was selected as a candidate for skin identification, showing good separation properties [Sauer et al. DOI:10.1016/j.fsigen.2017.02.002]. A study in rats demonstrated that the mir-203a expression in iliopsoas muscle decreased with lower body temperature and regulated Socs3 to suppress apoptosis via the Socs3-Casp3 axis under severe hypothermia [Umehara et al. DOI:10.1016/j.legalmed.2022.102150]. In human forensic science, the mir-203a was highly expressed in saliva, vaginal secretions, and menstrual blood but undetectable in venous blood, and it was used in a stepwise miRNA combination strategy to effectively differentiate saliva from other forensically relevant body fluids [Wang et al. DOI:10.1111/1556-4029.12730].