Basic Information

Symbol
hsa-mir-105-1
RNA class
miRNA miRNA hairpin
Alias
MIR105-1 MicroRNA 105-1 Hsa-MiR-105-5p Hsa-Mir-105-1 MIRN105-1 Hsa-Mir-105-P2_pre Hsa-MiR-105-3p MIMAT0000102 MIMAT0004516 Mir-105-1 MI0000111 hsa-mir-105
Location (GRCh38)
14:101060573-101060674
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-105-1
Sequence length
81 nt
GC content
0.5309

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-43.10 kcal/mol
Thermodynamic ensemble
Free energy: -44.78 kcal/mol
Frequency: 0.0653
Diversity: 6.35
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...(((((((((.((.((((((((((..((((((((..........))))))))..)))))))))).)))))))))))...
Thermodynamic Ensemble Prediction
...(((((((((,{{.((((((((((..((((((({.{.......}))))))))..)))))))))).}))))))))))...
Forensic Context

A review of human studies identified 197 miRNAs associated with wound healing, burn wound healing, and scarring, with specific expression patterns validated in human skin tissue and cell lines using qRT-PCR, microarrays, and next-generation sequencing [Siu et al. DOI:10.1111/wrr.13100]. A systematic review of the literature indicates that the mir-105 is inhibited by chronic morphine in the medial prefrontal cortex of rats, resulting in enhanced D1 receptor expression, and that its overexpression reduces morphine withdrawal conditioned place aversion [Occhipinti et al. DOI:10.3390/Ijms242317122].