Basic Information

Symbol
hsa-mir-206
RNA class
miRNA miRNA hairpin
Alias
MIR206 MicroRNA 206 Hsa-Mir-206 Hsa-MiR-206 MIRN206 Hsa-Mir-1-P2_pre MIMAT0000462 MI0000490 MiRNA206 Mir-206
Location (GRCh38)
6:52144349-52144434
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-206
Sequence length
86 nt
GC content
0.4535

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-43.70 kcal/mol
Thermodynamic ensemble
Free energy: -44.63 kcal/mol
Frequency: 0.9340
Diversity: 0.26
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
.((((.((((((((((((((((((((((((..(((((.{{(.....,).,))))).)))))))))))))))))))))))).)))).
Forensic Context

A study in humans demonstrated that mir-206 exhibited specific high expression in skeletal muscle, with a ΔΔCq >9.5 compared to other tissues including heart, and was confirmed in individual native samples and dried swabs [Sauer et al. DOI:10.1016/j.fsigen.2017.02.002]. A study in human heart tissue from road traffic accident victims demonstrated that the mir-206 showed a significant, time-dependent reduction in expression over a 196-hour post-mortem interval, with a 4-fold lower mean expression at 196 hours compared to 12 hours, exhibiting the strongest association and largest effect size among the miRNAs tested for PMI estimation [Singh et al. DOI:10.1016/j.scijus.2023.04.011]. A systematic review further noted the mir-206 has been studied in skeletal muscle for post-mortem interval estimation [Cianci et al. DOI:10.3390/ijms25158185].