Basic Information

Symbol
hsa-mir-208a
RNA class
miRNA miRNA hairpin
Alias
MIR208A MicroRNA 208a Hsa-Mir-208a Hsa-Mir-208 Hsa-MiR-208a-3p MicroRNA 208 MIRN208A MIRN208 Hsa-Mir-208-P2_pre Hsa-MiR-208a-5p MIMAT0026474 MIMAT0000241 MI0000251 MiRNA208 MIR208
Location (GRCh38)
14:23388596-23388666
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-208a
Sequence length
71 nt
GC content
0.5070

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-32.40 kcal/mol
Thermodynamic ensemble
Free energy: -33.31 kcal/mol
Frequency: 0.2278
Diversity: 1.66
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((.(((((((((((.((.((..((((((.(((...))).))))))..)).)).))))))))))).))))
Thermodynamic Ensemble Prediction
{(((.(((((((((({.((.((..((((((.(((...))).))))))..)).)).})))))))))).)))}
Forensic Context

A study in humans demonstrated that the mir-208a is a cardiac-specific miRNA deregulated in patients with acute coronary syndrome and acute myocardial infarction [Tong et al. DOI:10.3390/ijms19051467]. Research in a rat model of post-infarction heart failure identified rno-miR-208a-3p as significantly downregulated in heart failure tissue, with its expression increasing early post-myocardial infarction but decreasing in later stages, and therapeutic silencing of miR-208a is noted to prevent pathological cardiac remodeling [Liu et al. DOI:10.1371/journal.pone.0160920]. A study in mice demonstrated that the mir-208a showed a sustained increase in expression upon myocardial infarction specifically in cardiomyocytes compared to other cell types [Kumar Maji et al. DOI:10.1038/s41597-025-05061-1].