Forensic Context

A study in rats demonstrated that the miR-208a-3p was significantly downregulated in post-infarction heart failure tissue and exhibited a dynamic expression pattern, increasing early after myocardial infarction but decreasing gradually in the late stage [Liu et al. DOI:10.1371/journal.pone.0160920]. In humans, plasma levels of the miR-208a-3p were significantly elevated in patients with acute myocardial infarction compared to healthy controls, showing robust diagnostic performance as a circulating biomarker [Wang et al. DOI:10.1186/s40364-024-00690-x].