A study in rats demonstrated that the miR-208a-5p was significantly downregulated in post-infarction heart failure tissue and its expression was validated by qRT-PCR [Liu et al. DOI:10.1371/journal.pone.0160920]. Another investigation in rats showed that the miR-208a-5p was downregulated in heart tissue one hour after isoproterenol-induced cardiac injury, as identified via deep miRNA sequencing [Hosoya et al. DOI:10.1016/J.Legalmed.2024.102475].