Basic Information

Symbol
hsa-mir-21
RNA class
miRNA miRNA hairpin
Alias
MIR21 MicroRNA 21 Hsa-MiR-21-3p Hsa-MiR-21-5p Hsa-Mir-21 MIR-21 MIRN21 Hsa-Mir-21_pre MIMAT0000076 MIMAT0004494 MI0000077 MiRNA21
Location (GRCh38)
17:59841266-59841337
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Wound age identification
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-21
Sequence length
72 nt
GC content
0.4861

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-34.60 kcal/mol
Thermodynamic ensemble
Free energy: -36.07 kcal/mol
Frequency: 0.0924
Diversity: 3.51
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((((((((((((((.(((((.(((((.((((.((...))))))))))).)))))))))))))))))))))
Thermodynamic Ensemble Prediction
{(((((((((((((((.(((((.(((((.(((,,({...})))))))))).))))))))))))))))))))}
Forensic Context

A study in human brain tissue demonstrated that hsa-miR-21-5p is upregulated in traumatic brain injury (TBI) cases compared to non-traumatic controls and its expression is significantly higher in cases with short survival (<1 day) and in the critical–fatal TBI severity subgroup, while being lower in cases with long survival (>7 days) [Consalvo et al. DOI:10.3390/ijms25179539]. In human skin, the mir-21 is upregulated in burn hypertrophic scar tissue and its derived fibroblasts compared to normal controls, where it promotes keratinocyte proliferation and migration, stimulates re-epithelialisation, and is associated with scarring [Siu et al. DOI:10.1111/wrr.13100]. A study in humans demonstrated that serum levels of the mir-21 were significantly higher, up to 10-fold, in patients with erectile dysfunction (ED) alone compared to those with cardiovascular disease (CVD) alone or the combination of CVD and ED [Agulló et al. DOI:10.3389/fcvm.2024.1301925].