Forensic Context

A study in humans demonstrated that plasma-derived exosomes from male trauma patients with severe injury exhibited significant downregulation of the miR-210-3p compared to male operative controls, and this miRNA is involved in hematopoiesis and upregulated during erythroid differentiation [Munley et al. DOI:10.1097/TA.0000000000004225]. Separately, in human patients with septic shock, serum exosomal miRNA analysis identified the miR-210-3p as being downregulated compared to healthy controls [Li et al. DOI:10.1038/s41598-025-89946-6]. A study in *Sarcophaga peregrina* demonstrated that the miR-210-3p exhibits a continuous upregulation trend during pupal development, peaking around days 9–10, and polynomial regression models using its expression showed a strong correlation with pupal age (R² = 0.88–0.99), establishing a robust molecular framework for postmortem interval estimation [Xia et al. DOI:10.3390/insects16080754]. In humans, the miR-210-3p has been identified as a potential diagnostic biomarker for non-ST-elevation myocardial infarction, though its specificity in a forensic context was not evaluated in the provided study on marathon-induced cardiac strain [Shirvani Samani et al. DOI:10.3390/jcm11010005].