Forensic Context

A study in human denatured dermis from deep burn patients demonstrated that the mir-210 was down-regulated 0.0479-fold compared to paired normal skin, as validated by miRNA microarray and real-time RT-PCR [Liang et al. DOI:10.1016/j.burns.2011.10.014]. A separate review of human studies confirmed the mir-210 is down-regulated in deep partial thickness burn skin four days post-burn and is also down-regulated in burn hypertrophic scar tissue versus normal skin [Siu et al. DOI:10.1111/wrr.13100]. A study in mice demonstrated that the mir-210 expression increased at 3, 6, and 24 hours at the injury epicenter in a long spinal cord compression model, but only at 24 hours in a short compression model, with significant differences between models at 3 and 6 hours [Ziu et al. DOI:10.1016/j.spinee.2013.08.015]. In mammalian cells, the mir-210 is potently induced by hypoxia in a HIF-dependent manner and targets genes involved in mitochondrial function, DNA repair, cell cycle, and HIF stabilization [Nallamshetty et al. DOI:10.1016/j.freeradbiomed.2013.05.022].