Basic Information

Symbol
hsa-mir-211
RNA class
miRNA miRNA hairpin
Alias
MIR211 MicroRNA 211 Hsa-MiR-211-5p Hsa-Mir-211 MIRN211 Hsa-Mir-204-P1_pre Hsa-MiR-211-3p MIMAT0000268 MIMAT0022694 MI0000287 Mir-211
Location (GRCh38)
15:88611825-88611934
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Cause of death analysis Wound age identification
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-211
Sequence length
110 nt
GC content
0.5909

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-45.50 kcal/mol
Thermodynamic ensemble
Free energy: -47.10 kcal/mol
Frequency: 0.0744
Diversity: 7.78
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.....(((....(((((...(((((.(((((((((..(((((.((((...(((...))).)))))))))..))))))))).)))))...)))))...)))..........
Thermodynamic Ensemble Prediction
....{(({....(((((...(((((.(((((((((..(((((.((((...(((...))).)))))))))..))))))))).)))))...)))))...},.,,,...,}..
Forensic Context

A study in humans demonstrated that the mir-211 was downregulated in denatured dermis from deep partial thickness burn patients compared to paired normal skin, with a 0.0725-fold decrease measured by microarray and validated via RT-PCR [Liang et al. DOI:10.1016/j.burns.2011.10.014]. This differential expression was part of a broader profiling effort that identified 66 miRNAs altered in burn wounds, with the mir-211 specifically noted among the downregulated species [Siu et al. DOI:10.1111/wrr.13100]. A study in mice demonstrated that the mir-211 was significantly downregulated in serum during the early phase (log2 fold change = -7.21) following lethal total body irradiation (9.75 Gy) [Chakraborty et al. DOI:10.1038/s41598-020-62255-w].