Basic Information

Symbol
hsa-mir-214
RNA class
miRNA miRNA hairpin
Alias
MIR214 MicroRNA 214 Hsa-MiR-214-3p Hsa-MiR-214-5p Hsa-Mir-214 MIRN214 Hsa-Mir-214-V1_pre Hsa-Mir-214-V2_pre MIMAT0000271 MIMAT0004564 MI0000290 MiRNA214 Mir-214
Location (GRCh38)
1:172138798-172138907
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification Wound age identification Cause of death analysis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-214
Sequence length
110 nt
GC content
0.5636

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-67.50 kcal/mol
Thermodynamic ensemble
Free energy: -67.60 kcal/mol
Frequency: 0.8511
Diversity: 0.44
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.....((((((.....(((((((((((.((((((((((...((((((((((((.............))))))))))))...)))))))))).))))))))))))))))).
Thermodynamic Ensemble Prediction
.....((((((.....(((((((((((.((((((((((...((((((((((((.............))))))))))))...)))))))))).))))))))))))))))).
Forensic Context

A review of human studies found that the mir-214 is dysregulated in skin injury and scarring processes, being downregulated in deep partial thickness burn skin four days post-burn compared to normal skin [Siu et al. DOI:10.1111/wrr.13100]. A study in humans demonstrated that the mir-214 serves as a menstrual blood marker, with all tested menstrual blood samples showing a peak for this marker in a multiplex system that successfully identified body fluids and obtained STR profiles from the same sample [Li et al. DOI:10.1016/j.fsigen.2014.04.011]. In rhesus macaques, the mir-214 was identified as a feature in a dose-prediction model for thoracic radiation exposure at Day 3 post-irradiation [May et al. DOI:10.1038/s41598-022-16316-x].