Basic Information

Symbol
hsa-mir-215
RNA class
miRNA miRNA hairpin
Alias
MIR215 MicroRNA 215 Hsa-MiR-215-5p Hsa-Mir-215 MIRN215 Hsa-Mir-192-P1_pre Hsa-MiR-215-3p MIMAT0000272 MIMAT0026476 MI0000291 MiRNA215 Mir-215
Location (GRCh38)
1:220117853-220117962
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-215
Sequence length
110 nt
GC content
0.3455

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-33.00 kcal/mol
Thermodynamic ensemble
Free energy: -35.41 kcal/mol
Frequency: 0.0199
Diversity: 11.13
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...........(((((((((((((...((.((((.(((.((((((((((...........)))))))))).)))..)))).))...)))))))).)))))..........
Thermodynamic Ensemble Prediction
........{,.{((((((((((((...((.((((.(((.((((((((((..,........)))))))))).)))..)))).))...)))))))),,)))).,,.......
Forensic Context

A study in humans demonstrated that the mir-215 was significantly downregulated in plasma at 48 hours post-injury in patients with isolated traumatic spinal cord injury compared to healthy controls, as validated by droplet digital PCR [Hörauf et al. DOI:10.3390/ijms262210954]. A study in rhesus macaques (Macaca mulatta) following whole thorax irradiation identified the mir-215 as a dose-dependent marker, showing altered expression conserved between non-human primates and mice [May et al. DOI:10.1038/s41598-022-16316-x]. The mir-215 was also utilized as a feature in a Day 21 four-group survival prediction model developed from serum miRNA analysis, demonstrating its role in forecasting survival outcomes in this large animal model of radiation exposure.