Forensic Context

A study in humans demonstrated that the mir-215 was significantly downregulated in plasma at 48 hours post-injury in patients with isolated traumatic spinal cord injury compared to healthy controls, as validated by droplet digital PCR [Hörauf et al. DOI:10.3390/ijms262210954]. A study in rhesus macaques (Macaca mulatta) following whole thorax irradiation identified the mir-215 as a dose-dependent marker, showing altered expression conserved between non-human primates and mice [May et al. DOI:10.1038/s41598-022-16316-x]. The mir-215 was also utilized as a feature in a Day 21 four-group survival prediction model developed from serum miRNA analysis, demonstrating its role in forecasting survival outcomes in this large animal model of radiation exposure.