Basic Information

Symbol
hsa-mir-216a
RNA class
miRNA miRNA hairpin
Alias
MIR216A MicroRNA 216a Hsa-Mir-216a Hsa-Mir-216 Hsa-MiR-216a-5p MicroRNA 216 MIRN216A MIRN216 Hsa-Mir-216-P2b_pre Hsa-MiR-216a-3p MIMAT0000273 MIMAT0022844 MI0000292 MiRNA216 Mir-216a Mir-216 MIR216
Location (GRCh38)
X:138667711-138667793
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification Mechanical injury analysis Tissue/body fluid identification
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-216a
Sequence length
110 nt
GC content
0.4727

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-40.30 kcal/mol
Thermodynamic ensemble
Free energy: -41.76 kcal/mol
Frequency: 0.0940
Diversity: 13.17
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((.(((((.((((((((.(((((((((..(((.((((((((.(((....)))....)))))))).))).))))))))).)))))..........))).))))).))....
Thermodynamic Ensemble Prediction
((.(((((.((((((((.(((((((((..(((.((((((((.{((....}}},,..)))))))).))).))))))))).)))))..........})).))))).))....
Forensic Context

A study in humans demonstrated that the mir-216a-5p was upregulated 24 hours post-injury in skin wounds compared to unwounded skin [Siu et al. DOI:10.1111/wrr.13100]. A study in humans demonstrated that the mir-216a-5p is downregulated in fracture hematoma and its expression level increases with longer intervals between trauma and surgery, where it enhances osteogenic differentiation and bone formation and mediates chondrocyte proliferation and migration [Rald Victor Maria Groven et al. DOI:10.1016/j.jot.2022.07.002]. In mice, the mir-216a-5p showed a longitudinal increase in plasma abundance in C57Bl/6 mice after whole thorax irradiation and was differentially expressed in C3H lung tissue, identifying it as a circulating and tissue injury marker [Rogers et al. DOI:10.1371/journal.pone.0232411].