Forensic Context

A study in humans demonstrated that the mir-216a-5p was upregulated 24 hours post-injury in skin wounds compared to unwounded skin [Siu et al. DOI:10.1111/wrr.13100]. A study in humans demonstrated that the mir-216a-5p is downregulated in fracture hematoma and its expression level increases with longer intervals between trauma and surgery, where it enhances osteogenic differentiation and bone formation and mediates chondrocyte proliferation and migration [Rald Victor Maria Groven et al. DOI:10.1016/j.jot.2022.07.002]. In mice, the mir-216a-5p showed a longitudinal increase in plasma abundance in C57Bl/6 mice after whole thorax irradiation and was differentially expressed in C3H lung tissue, identifying it as a circulating and tissue injury marker [Rogers et al. DOI:10.1371/journal.pone.0232411].