Basic Information

Symbol
hsa-mir-216b
RNA class
miRNA miRNA hairpin
Alias
MIR216B MicroRNA 216b Hsa-Mir-216b Hsa-MiR-216b-5p MIRN216B Hsa-Mir-216-P2a_pre Hsa-MiR-216b-3p MIMAT0004959 MIMAT0026721 MI0005569 Mir-216b
Location (GRCh38)
X:50009722-50009805
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-216b
Sequence length
82 nt
GC content
0.4512

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-32.30 kcal/mol
Thermodynamic ensemble
Free energy: -33.57 kcal/mol
Frequency: 0.1266
Diversity: 4.18
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((((((...(((((((((.((.((.((((((.((......)).))))))...)).)).)))))))))...)))))))...
Thermodynamic Ensemble Prediction
,(((((((...(((((((((.((.{{.((((((.((......)).))))))...}}.)).)))))))))...))))))).,.
Forensic Context

A study in human patients with coronary artery disease identified the mir-216b as a biomarker for recurrent myocardial infarction risk, where it was downregulated in whole blood samples from patients with recurrent MI compared to those without, with this differential expression meeting a false discovery rate correction threshold of less than 0.1 [Onuoha et al. DOI:10.1111/cts.13307]. The analysis found no significant differential expression for this miRNA in plasma samples, and the research concluded that whole blood is the preferred sample source for miRNA profiling related to thrombotic risk prognosis.