Basic Information

Symbol
hsa-mir-218-2
RNA class
miRNA miRNA hairpin
Alias
MIR218-2 MicroRNA 218-2 Hsa-MiR-218-2-3p Hsa-MiR-218-5p Hsa-Mir-218-2 MIRN218-2 Hsa-Mir-218-P4_pre MIMAT0000275 MIMAT0004566 Mir-218-2 MI0000295
Location (GRCh38)
7:74191198-74191294
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification Other applications
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-218-2
Sequence length
110 nt
GC content
0.5545

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-44.60 kcal/mol
Thermodynamic ensemble
Free energy: -46.51 kcal/mol
Frequency: 0.0451
Diversity: 7.67
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...(((..((.((((.(((((((...(((((((((..((((((((..((............))..))))))))..)))))))))...))))))).))))))....)))..
Thermodynamic Ensemble Prediction
...,{{..((.((((.(((((((.,.(((((((((..((((((((..((...,....,...)}..))))))))..))))))))).,.))))))).))))))....,,}..
Forensic Context

A review of human studies identified 197 miRNAs associated with wound healing, burn wound healing, and scarring, with the mir-218-2 being downregulated 4 days post-burn in deep partial thickness burn skin versus normal skin and downregulated 24 hours post-injury in skin wounds versus unwounded skin [Siu et al. DOI:10.1111/wrr.13100]. A study in rhesus macaques demonstrated that the mir-218-2 was utilized as a feature in a four-group survival prediction model at Day 3 and in a pleural effusion prediction model by gender at Day 21 following whole thorax irradiation [May et al. DOI:10.1038/s41598-022-16316-x].