Basic Information

Symbol
hsa-mir-22
RNA class
miRNA miRNA hairpin
Alias
MIR22 MicroRNA 22 Hsa-MiR-22-3p Hsa-MiR-22-5p Hsa-Mir-22 MIRN22 Hsa-Mir-22-P1b_pre MIMAT0000077 MIMAT0004495 MI0000078 MiR-22
Location (GRCh38)
17:1713903-1713987
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-22
Sequence length
85 nt
GC content
0.5412

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-39.80 kcal/mol
Thermodynamic ensemble
Free energy: -41.47 kcal/mol
Frequency: 0.0670
Diversity: 5.46
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((.(((..((((((((((((((((((((.((((((.((.........))))))))))))).))))))))))))))).))).)))
Thermodynamic Ensemble Prediction
(((.(((..(((((((((((((((((((,,((((((.(,.,,,...}})}))))))))))).))))))))))))))).))).)))
Forensic Context

A study in humans identified hsa-miR-22-5p as a candidate for differentiating venous blood from menstrual blood in forensic body fluid identification, but it showed no larger difference between these fluids and was expressed at similar levels across all tested body fluids, leading to its exclusion from the final analytical panel [Sauer et al. DOI:10.1016/j.fsigen.2016.01.018]. A study in mice demonstrated that overexpression of the mir-22 in irradiated bone marrow mesenchymal stem cells promoted apoptosis and suppressed osteogenic capacity [Jia et al. DOI:10.3389/fcell.2022.861451]. In human forensic samples, the mir-22 was reported in published data as a potential marker for saliva, though it was not selected as an absolute specific marker in a comprehensive sequencing study of six body fluids/tissues [Liu et al. DOI:10.3390/genes13091530].