Basic Information

Symbol
hsa-mir-221
RNA class
miRNA miRNA hairpin
Alias
MIR221 MicroRNA 221 Hsa-MiR-221-3p Hsa-MiR-221-5p Hsa-Mir-221 MIRN221 Hsa-Mir-221-P2a_pre MIMAT0000278 MIMAT0004568 MI0000298 MiRNA221 Mir-221
Location (GRCh38)
X:147199044-147199127
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Wound age identification
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-221
Sequence length
110 nt
GC content
0.4727

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-46.50 kcal/mol
Thermodynamic ensemble
Free energy: -48.76 kcal/mol
Frequency: 0.0254
Diversity: 9.59
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.((((((((((((....(((.(((((((((((.(((((((((....(((((((.....))).))))))))))))).))))))).)))).))))))))))....)))))..
Thermodynamic Ensemble Prediction
.((((((((((((....(((.(((((((((((.(((((((((....((((({{,....))),})))))))))))).)))))))))))).))))))))))....)))))..
Forensic Context

A study in humans demonstrated that hsa-miR-221 showed direct correlations with TLR4 (P = .02), MyD88 (P < .01), and TRAM (P = .03) gene expression in the whole blood of severely injured trauma patients compared to healthy controls [Uhlich et al. DOI:10.1016/j.surg.2014.06.017]. A separate review of human skin studies reported that the mir-221 was downregulated in burn hypertrophic scar tissue compared to normal skin [Siu et al. DOI:10.1111/wrr.13100].