Forensic Context

A study in human denatured dermis from deep partial-thickness burn patients demonstrated that the mir-222 was downregulated to 0.1244-fold compared to paired normal skin at four days post-burn [Liang et al. DOI:10.1016/j.burns.2011.10.014]. A subsequent review of human skin burns, wound healing, and scarring confirmed this downregulation in burn-injured skin and further reported that the mir-222 was also downregulated in burn-induced hypertrophic scar tissue compared to normal skin [Siu et al. DOI:10.1111/wrr.13100]. A study in rats demonstrated that the mir-222 is downregulated in both corpus cavernosum tissue and peripheral blood in a diabetic-alcohol consumption model of endothelial dysfunction, with this downregulation correlating with impaired endothelium-dependent relaxation [Tiraboschi et al. DOI:10.1016/j.esxm.2021.100326]. In traumatic brain injury research, the mir-222 was identified as a potential biomarker, being downregulated in the rat dorsal hippocampus at 24 hours post-moderate injury [Martinez & Peplow DOI:10.4103/1673-5374.219025].