Basic Information

Symbol
hsa-mir-106b
RNA class
miRNA miRNA hairpin
Alias
MIR106B MicroRNA 106b Hsa-MiR-106b-3p Hsa-MiR-106b-5p Hsa-Mir-106b MIRN106B Hsa-Mir-17-P1d_pre MIMAT0004672 MIMAT0000680 MI0000734 Mir-106b
Location (GRCh38)
8:22244962-22245043
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Mechanical injury analysis Tissue/body fluid identification Chronological age estimation Other applications
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-106b
Sequence length
82 nt
GC content
0.6098

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-44.40 kcal/mol
Thermodynamic ensemble
Free energy: -45.02 kcal/mol
Frequency: 0.3652
Diversity: 3.16
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
(((((.(((((..(((((((.(((((((.(.((((((......))..))))}.))))))).)))))))...))))).)))))
Forensic Context

A study in humans demonstrated that the mir-106b was significantly increased in the plasma of acute myocardial infarction patients compared to healthy controls via next-generation sequencing, though subsequent RT-qPCR validation in an independent cohort showed no significant difference [Baulina et al. DOI:10.1016/j.yjmcc.2018.07.129]. In a separate human study of severe trauma, the mir-106b showed direct correlations with arterial blood gas HCO3 and base deficit, clinical parameters of injury severity [Uhlich et al. DOI:10.1016/j.surg.2014.06.017]. A review of human forensic studies indicates the mir-106b is recognized as a venous blood-specific miRNA and as an age-related biomarker, showing down-regulation with aging, and has been found decreased in plasma and serum in lung cancer [Silva et al. DOI:10.1016/J.Fsigen.2014.09.002]. In the context of male infertility, the mir-106b is highly expressed in the seminal plasma of asthenozoospermic and azoospermic patients and functions as a biological regulator, promoting proliferation and DNA synthesis in mouse spermatogonial stem cells by targeting Stat3 and Ccnd1 [Ahmed S. Doghish et al. DOI:10.1007/s00210-024-03594-7].