Basic Information

Symbol
hsa-mir-23c
RNA class
miRNA miRNA hairpin
Alias
MIR23C MicroRNA 23c Hsa-Mir-23c Hsa-MiR-23c MIMAT0018000 MI0016010 Mir-23c
Location (GRCh38)
4:52712682-52712747
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-23c
Sequence length
100 nt
GC content
0.4500

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-33.80 kcal/mol
Thermodynamic ensemble
Free energy: -35.15 kcal/mol
Frequency: 0.1119
Diversity: 7.70
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
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Forensic Context

A study in humans with coronary artery disease identified the mir-23c as a biomarker for recurrent myocardial infarction risk, demonstrating it was downregulated in whole blood of patients with recurrent MI compared to those without, with this differential expression remaining significant after false discovery rate correction (FDR <0.1) [Onuoha et al. DOI:10.1111/cts.13307]. The investigation found this miRNA was not significantly different in plasma samples, indicating whole blood as the preferred sample source for its detection in this clinical prognostic context.