Basic Information
Symbol
hsa-miR-23c
RNA class
miRNA
mature miRNA
Alias
hsa-miR-23c
MIR23C
MicroRNA 23c
Location (GRCh38)
-
Forensic tag(s)
Sudden cardiac death diagnosis
External database
Sequence & Structure
Secondary Structure
Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-33.80 kcal/mol
Thermodynamic ensemble
Free energy:
-35.15 kcal/mol
Frequency:
0.1119
Diversity:
7.70
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
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Forensic Context
A study in humans with coronary artery disease identified the miR-23c as a biomarker for recurrent myocardial infarction risk, demonstrating it was downregulated in whole blood of patients with recurrent MI compared to those without, with this differential expression remaining significant after false discovery rate correction (FDR <0.1) [Onuoha et al. DOI:10.1111/cts.13307]. The investigation found this miRNA was not significantly different in plasma samples, indicating whole blood as the preferred sample source for its detection in this clinical prognostic context.