Forensic Context

A study in humans identified the miR-106b-5p as a diagnostic biomarker for acute myocardial infarction, where its expression in plasma exosomes showed a downregulated pattern from healthy to coronary artery disease to AMI groups, and it was part of an 18-miRNA panel achieving an AUC of 0.87 for AMI detection [Guo et al. DOI:10.21037/atm-20-2337]. In Wistar rats, the miR-106b-5p was upregulated 2.94-fold in the striatum following heroin exposure, indicating its role as a biomarker for substance addiction [Pence et al. DOI:10.1007/S00221-024-06972-Y]. A study in humans demonstrated that the miR-106b-5p is upregulated in the prefrontal cortex of subjects with schizophrenia (fold-change 1.22) and bipolar disorder (fold-change 1.18) [Smalheiser et al. DOI:10.1371/journal.pone.0086469].