Basic Information

Symbol
hsa-mir-25
RNA class
miRNA miRNA hairpin
Alias
MIR25 MicroRNA 25 Hsa-MiR-25-3p Hsa-MiR-25-5p Hsa-Mir-25 MIRN25 Hsa-Mir-92-P2d_pre MIMAT0000081 MIMAT0004498 MI0000082 MiR-25
Location (GRCh38)
7:100093560-100093643
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Sudden death from CNS diseases Other applications
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-25
Sequence length
84 nt
GC content
0.6310

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-35.90 kcal/mol
Thermodynamic ensemble
Free energy: -37.94 kcal/mol
Frequency: 0.0363
Diversity: 11.14
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((.((((((..((((.(((((..(.(((((..((((........))))..))))).)..))))).))))..)))))).))))
Thermodynamic Ensemble Prediction
((((.(({(((..((((.(((((..(.(((({,(((((.......}}..)))))))).)..))))).))))..)))})).))))
Forensic Context

A study in humans identified hsa-miR-25-5p as up-regulated in the plasma of young patients with ST-segment elevated myocardial infarction (STEMI) via small RNA sequencing, though it was not validated by subsequent qRT-PCR [Tong et al. DOI:10.3390/ijms19051467]. A separate meta-analysis in humans found hsa-miR-25-3p to be up-regulated in the saliva of patients with mild traumatic brain injury, where it was associated with specific signaling pathways [Matyasova et al. DOI:10.4149/gpb_2021038]. A study in non-human primates (Macaca mulatta) demonstrated that plasma levels of the mir-25 at or below the median abundance at day 15 post whole-thorax lung irradiation were associated with statistically significant reduced survival, correlating with late radiation injury [Rogers et al. DOI:10.1667/RADE-20-00031.1].