Basic Information

Symbol
hsa-mir-26b
RNA class
miRNA miRNA hairpin
Alias
MIR26B MicroRNA 26b Hsa-MiR-26b-5p Hsa-Mir-26b MIRN26B Hsa-Mir-26-P2_pre Hsa-MiR-26b-3p MIMAT0004500 MIMAT0000083 MI0000084 MiR-26b
Location (GRCh38)
2:218402646-218402722
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification Cause of death analysis
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-26b
Sequence length
77 nt
GC content
0.5584

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-40.20 kcal/mol
Thermodynamic ensemble
Free energy: -40.91 kcal/mol
Frequency: 0.3172
Diversity: 2.03
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
((((..(((((,{((((((((..(((((((((((.(......))))))))))))..))))))))))).)))..))))
Forensic Context

A study in human organ tissues evaluated the mir-26b as a candidate reference gene for miRNA qPCR normalization in forensic organ tissue identification, finding it among the least stable genes in a pooled sample set and excluding it from further analysis [Sauer et al. DOI:10.1016/j.fsigen.2014.08.005]. A separate study in human trauma patients demonstrated that the mir-26b was significantly upregulated in circulating T cells during the injury stage compared to the recovery stage, though it had no connections to downregulated mRNA targets in the identified interactome [Rau et al. DOI:10.2147/JIR.S375881]. A study in humans demonstrated that the mir-26b is significantly downregulated in platelets from septic patients compared to healthy controls, with its attenuated levels correlating with disease severity and 28-day mortality [Szilágyi et al. DOI:10.3390/ijms21030866].