Forensic Context

A study in human peripheral blood mononuclear cells demonstrated that the miR-107 is upregulated at a 1 Gy radiation dose and is a potential biomarker for radiation response, with predicted interactions targeting genes involved in neurotrophin signaling and the renin-angiotensin system [Lee et al. DOI:10.1155/2014/456323]. In a separate investigation of human plasma from young patients with acute coronary syndrome, the miR-107 was identified as up-regulated in STEMI patients via small RNA sequencing [Tong et al. DOI:10.3390/ijms19051467]. In a spinal cord injury mouse model, the miR-107 was overexpressed at the injury epicenter at 3 and 6 hours after decompression in a long compression model, with a statistically significant difference between compression durations observed at 6 hours [Ziu et al. DOI:10.1016/j.spinee.2013.08.015].