Basic Information

Symbol
hsa-mir-27b
RNA class
miRNA miRNA hairpin
Alias
MIR27B MicroRNA 27b Hsa-MiR-27b-5p Hsa-MiR-27b-3p Hsa-Mir-27b MIR-27b MIRN27B Hsa-Mir-27-P2_pre MIMAT0000419 MIMAT0004588 MI0000440 MiRNA27B
Location (GRCh38)
X:45746157-45746266
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Wound age identification
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-27b
Sequence length
97 nt
GC content
0.4742

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-49.40 kcal/mol
Thermodynamic ensemble
Free energy: -52.14 kcal/mol
Frequency: 0.0117
Diversity: 10.53
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((((((....(((((((((((((((((.((((.(((((((....(((...)))..))))))))))))))))))))))))))))..)))).)))).
Thermodynamic Ensemble Prediction
((((((((....(((((((((((((((((.(({.((((((((,(..,{,...}))).,)))))))})))))))))))))))))))..))))}}))).
Forensic Context

A study in humans demonstrated that the mir-27b was downregulated in serum at baseline (within one hour of injury) in patients with mild traumatic brain injury compared to matched controls, leading to its classification as a potential biomarker for mTBI [Polito et al. DOI:10.1007/s11033-020-05386-7]. However, it was subsequently excluded from the final biomarker panel as it was deemed not suitable for this application in the study's experimental context. A study in rats with deep second-degree scald burns demonstrated that inhibition of the mir-27b significantly accelerated wound healing, increased fibroblast growth in skin tissues, and upregulated the expression of MMP-1, α-SMA, collagen I, and collagen III [Bi et al. DOI:10.3892/etm.2020.9191].