Basic Information

Symbol
hsa-mir-28
RNA class
miRNA miRNA hairpin
Alias
MIR28 MicroRNA 28 Hsa-MiR-28-5p Hsa-MiR-28-3p Hsa-Mir-28 MIRN28 Hsa-Mir-28-P1_pre MIMAT0000085 MIMAT0004502 MI0000086 MiR-28
Location (GRCh38)
2:32532153-32532246
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Sudden cardiac death diagnosis Individual identification Sudden death from CNS diseases
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-28
Sequence length
86 nt
GC content
0.5233

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-50.20 kcal/mol
Thermodynamic ensemble
Free energy: -51.26 kcal/mol
Frequency: 0.1786
Diversity: 5.16
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((.(((((((((.((((((((((((((((.(((((((......)))))....)).)))))))))))))))).))))))))).)))
Thermodynamic Ensemble Prediction
(((.(((((((((.((((((((((((((((.{((((((......))))),...}}.)))))))))))))))).))))))))).))}
Forensic Context

A study in human myocardial autopsy specimens demonstrated that the mir-28 was up-regulated in the hearts of patients deceased with sepsis compared to non-septic controls [Pasi Lehto et al. DOI:10.1038/s41598-024-81114-6]. In a separate human postmortem study, the mir-28 was significantly decreased in plasma-derived exosomes from subjects with acute myocardial infarction compared to controls, identifying it as a potential biomarker for this condition [Kim et al. DOI:10.3390/ijms25179619]. A study in humans demonstrated that the mir-28 was differentially expressed between monozygotic twins in peripheral blood, identified by massively parallel sequencing in pair 2, though this differential expression was not confirmed by subsequent real-time PCR validation [Fang et al. DOI:10.1016/j.fsigen.2018.09.011]. A separate review noted the mir-28 is detected in the substantia nigra of Parkinson's disease patients [Das et al. DOI:10.1080/21655979.2021.2003667].