Basic Information

Symbol
hsa-let-7c
RNA class
miRNA miRNA hairpin
Alias
MIRLET7C MicroRNA Let-7c Hsa-Let-7c-5p Hsa-Let-7c MIRNLET7C Hsa-Let-7-P1c_pre Hsa-Let-7c-3p MIMAT0026472 MIMAT0000064 MI0000064 Let-7c LET7C
Location (GRCh38)
21:16539828-16539911
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-let-7c
Sequence length
84 nt
GC content
0.4762

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-31.60 kcal/mol
Thermodynamic ensemble
Free energy: -33.16 kcal/mol
Frequency: 0.0796
Diversity: 7.72
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
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Thermodynamic Ensemble Prediction
((.((((((..(((.(((.(((((((((((((..((.(,.(,...}).,).)}))))))))))))).))).)))..))))))))
Forensic Context

A review of human studies identified 197 miRNAs associated with wound healing, burn wound healing, and scarring, with the let-7c being downregulated in deep partial thickness burn skin four days post-burn compared to normal skin and also downregulated in heat-shocked fibroblasts and in skin wounds [Siu et al. DOI:10.1111/wrr.13100]. In a separate human astrocyte model, extracellular vesicle-derived hsa-let-7c-5p was significantly downregulated after 3 Gy proton radiation exposure and targets genes associated with cognitive delay and epileptic encephalopathy [Deriesha Gaines et al. DOI:10.1016/j.lssr.2021.11.001].