Basic Information

Symbol
hsa-mir-29a
RNA class
miRNA miRNA hairpin
Alias
MIR29A MicroRNA 29a Hsa-MiR-29a-5p Hsa-MiR-29a-3p Hsa-Mir-29a Hsa-Mir-29 MicroRNA 29 MIRN29A MIRN29 Hsa-Mir-29-P2b_pre MIMAT0000086 MIMAT0004503 MI0000087 MiRNA29A Mir-29a
Location (GRCh38)
7:130876747-130876810
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Wound age identification
External database
HGNC NCBI Ensembl OMIM miRBase RNAcentral

Sequence & Structure

Transcript ID
hsa-mir-29a
Sequence length
64 nt
GC content
0.3281

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-24.60 kcal/mol
Thermodynamic ensemble
Free energy: -25.12 kcal/mol
Frequency: 0.4278
Diversity: 2.03
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((((((((((...(((((((.((((...........)))))))))))...))))))))))))
Thermodynamic Ensemble Prediction
{(((((((((((...(((((((.((((...........)))))))))))...)))))))))))}
Forensic Context

A study in humans demonstrated that the mir-29a is downregulated 4 days post-burn in deep partial thickness burn skin compared to normal skin [Siu et al. DOI:10.1111/wrr.13100], and another study in human trauma patients found the mir-29a is markedly upregulated in plasma and contains pro-inflammatory nucleotide motifs, with its expression showing strong diagnostic ability for trauma severity and associated injuries [Ren et al. DOI:10.1016/j.isci.2025.113569]. The literature also notes that miR-29a reduces collagen type I levels and exerts anti-fibrotic effects by inhibiting TGF-β/Smad3 signaling [Badanina et al. DOI:10.3390/ijms262010060].